Single domain antibody

Single domain antibody (sdAb), also called nanobodies, is the variable region isolated from the antigen-binding variable domain (VHH) of camel heavy-chain only antibody or the variable domain (vNAR) of cartilaginous fish immunoglobulin new antigen receptor (IgNAR). With a size of just 15 kDa (2~4 nm), sdAb is the smallest antigen-binding fragment today discovered.

Given its small dimension, sdAb offers a series of advantages that cannot be overlooked:

  • Improved tissue penetration
  • Ability to trespass the blood-brain barrier
  • Unique recognition of a hidden epitope
  • Optimal affinity and specificity
  • Highly stable over a wide range of pHs and temperatures
  • Highly soluble
  • Rapid clearance
  • Easily re-formatted for different downstream applications
  • Cost-effective
  • Possibility of large-scale production

Our Offering

SdAb discovery services:

  • Immunized camelids sdAb phage library
  • Naïve camelids sdAb phage library
  • Immunized shark sdAb phage library

SdAb-based research reagents:

  • Primary antibody
  • Secondary antibody
  • Conjugated/unconjugated antibody

Jotbody (HK) Limited is a biotechnology company on the cutting edge of single-domain antibody discovery, production, and application.

Jotbody is dedicated to offering single-domain antibody discovery CRO services and single-domain antibody-based research reagents of outstanding quality to the global scientific community at unbeatable prices.

 We offer high-quality products, excellent customer service & technical support:

  • Year-round immunization
  • Customizable project
  • Stress-free animals with clean immune background
  • Immunized and naïve libraries
  • Multiple host animals available for immunization(camel, alpaca, llama, shark) & vectors (bacterial, mammalian, and insect cells)
  • Quality assurance (qualified antigen quality, adequate immune titer, mega library)
  • Short-cycle workflow
  • Proven scientific know-how
  • Reliable lab report with timely update
  • Unbeatable prices & 100% success rate

Single Domain Antibody (sdAb) is the smallest known antigen-binding fragment. There is great expectation on the use of sdAb for diagnosis and therapeutics purposes.

Jotbody is specialized in the discovery and production of sdAb from Camel, Alpaca, Llama and Shark.

Not only services, Jotbody provides a wide selection of sdAb for different applications and ready for you. Our catalog is continuously up-dated. Contact us if you dont find your product.